Improved method for assembly of hemeprotein neuronal NO-synthase heterodimers
نویسندگان
چکیده
منابع مشابه
Normal vascular development in mice deficient in endothelial NO synthase: possible role of neuronal NO synthase.
PURPOSE Nitric oxide formation by nitric oxide synthase (NOS) has been implicated in vascular injury and retinal neovascularization during oxygen-induced retinopathy. However, the role of NOS in normal retinal vascular development and growth has not been studied. The purpose of these experiments was to characterize the expression of NOS in relation to vascular development and to determine the e...
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The nitric oxide synthases (NOSs) are dimeric flavocytochromes consisting of an oxygenase domain with cytochrome P450-like Cys-ligated haem, coupled to a diflavin reductase domain, which is related to cytochrome P450 reductase. The NOSs catalyse the sequential mono-oxygenation of arginine to N-hydroxyarginine and then to citrulline and NO. The constitutive NOS isoforms (cNOSs) are regulated by ...
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ژورنال
عنوان ژورنال: Analytical Biochemistry
سال: 2016
ISSN: 0003-2697
DOI: 10.1016/j.ab.2016.07.031